
Deplin PRO Mood Health™ brings together four key nutrients in a multi-action formula that helps restore the biological balance needed for mood, stress, and cognitive function — supporting your ongoing depression care. It has over 15 years of clinical data and has helped millions of patients manage their depression. It directly supports individuals with MTHFR Gene Mutations, which inhibit the conversion of synthetic folic acid to usable folate, often aiding in the treatment of depressive symptoms. Deplin PRO Mood Health contains 15mg of L-Methylfolate, 2000 IU of Vitamin D3, 25mg of Zinc Bisglycinate and 250mg of L-Theanine.
Up to 70% of depressed patients have an MTHFR genetic mutation hindering folate conversion. L-methylfolate bypasses this, providing the active nutrient directly to the brain. MTHFR gene mutations (specifically C677T and A1298C) can lead to reduced production of neurotransmitters like serotonin, dopamine, and norepinephrine. This deficiency can negatively affect mood, contributing to depression, anxiety, bipolar disorder, ADHD, and chronic fatigue.
L-methylfolate (a bioavailable form of vitamin B9) aids mood by acting as a crucial cofactor in producing neurotransmitters that regulate emotions, including serotonin, dopamine, and norepinephrine.
Vitamin D3 and Zinc play essential, distinct roles in supporting brain health and mood regulation. Research suggests they work by modulating neurotransmitters, reducing brain inflammation, and supporting the growth and repair of neurons.
L-theanine has established anti-stress and anxiolytic (anxiety-reducing) properties. It acts within 30–40 minutes to create a calming effect. Studies also indicate that L-theanine can reduce depression-like symptoms and improve mood.
Nutrition influences the biochemical processes that support mood. For people with depression whose nutritional needs cannot be met through dietary changes alone, DEPLIN PRO® offers a clinical option as part of their overall depression care. This can enhance the brain's natural ability to regulate mood and cognition, setting the foundation for effective depression treatment response. For more information on Deplin PRO Mood Health, visit deplin.com
Deplin PRO Mood Health has been shown to help traditional medications work better by optimizing brain chemistry, specifically by increasing neurotransmitter production (serotonin, dopamine, norepinephrine) needed for positive treatment response. By correcting nutrient deficiencies, it may improve the efficacy of mental health treatments. Deplin PRO is safe to use with all other depression medications and has no known drug-to-drug interactions. Studies show it is as safe as placebo.
Deplin PRO Mood Health can be used in conjunction with Transcranial Magnetic Stimulation (TMS) and improve outcomes by increasing neurotransmitter production (serotonin, dopamine, norepinephrine) needed for positive treatment response.

Below is an order request form. Please fill out the form completely and a prescription (order) will be sent to Brand Direct Health Pharmacy within one business day. Please be sure to include your full name, DOB, phone and address to expedite your order.

Brand Direct Health Mail Order Pharmacy will reach out to you approximately one business day after you submit the form below. Your name and DOB will be required to verify your identity. BDH will gather your billing and verify shipping information.

If you don't receive a call within one business day, please reach out directly to BDH at (866) 331-6440.
(your phone may be blocking their call)

3-Months of Deplin PRO is $199 plus shipping. To get $50 off your first order, use coupon code "FIRSTDPMH50". (Only $149)
Be sure to note this code, as it will be required. A monthly payment option is available to those who need it. (Request a monthly payment plan with your BDH agent.)

If after 90-Days, Deplin PRO Mood Health hasn't improved your mood health, BDH Pharmacy will give you a full refund on your initial order.
Deplin PRO is as safe as placebo and has no drug-to-drug interactions. It is taken once per day, with or without food, at a time convenient for you.
Begin your Deplin PRO journey today.
AUTHORIZATION FOR THE RELEASE OF PROTECTED HEALTH INFORMATION
By submitting the order request form below, I authorize the use of the information provided to be shared with BDH Pharmacy, solely for the purpose to fill my order. This information will not be used for any other purpose, nor shared or sold to any 3rd party.
We use cookies to analyze website traffic and optimize your website experience. By accepting our use of cookies, your data will be aggregated with all other user data.